step three.step 3. Chance Products
Compared with men with BMI? 25 kg/m 2 , the age-adjusted risk of osteoporosis was over four-fold higher in those with BMI < 25 (odds ratio (OR) 4.4 (1.51, ) in age-adjusted model (Table 3). The association between BMI and osteopenia was similar among overweight/obese and normal weight men, although not statistically significant (Table 3).
One another Bmi and you will pounds were synchronised which have BMD, and you may BMC indications therefore the most powerful Pearson’s relationship coefficients have been discovered anywhere between lbs and you may BMC overall hip and trochanter places and you will the weakest of these were between Bmi and femoral neck BMC. New correlations ranging from many years and you will BMD and you will BMC evidence were negative (Dining table 4).
This-adjusted ratio from BMD and you can BMC variation informed me because of the Body mass index and you can pounds was revealed in the Desk 5. Lbs tended to reveal greater differences free escort web site in BMD and you may BMC delivery whatsoever new studied skeletal internet sites as compared to Body mass index. This was mirrored of the steeper mountain (?) of your own respective linear regression outlines. Ideal difference between BMD and you can BMC shipment checked in the trochanter BMC accompanied by lumbar BMC having lbs. Lbs is a vital predictor away from BMD and you can BMC type during the more mature Iranian people.
In this study, both BMI and weight were associated with BMD, and obesity significantly decreased the risk for osteoporosis in men. These results are consistent with most previous studies, particularly in postmenopausal women, which indicated that lower BMI and weight were associated with lower BMD. Prospective studies found that the early postmenopausal women who have low BMI lose more bones compared to those with higher BMI tertiles [4, 8]. In other cross-sectional studies, however, thinness is related to both osteoporosis and increased fracture risk [10, 11]. Iqbal et al. found that low BMI is a good indicator for referral of women less than 60 years old for measurements of BMD. Similar studies also reported a consistent finding that lower BMI was associated with lower BMD [5, 6, 28]. In a study similar to ours, those with lower BMI were at higher risk of low BMD . The Studies of National Osteoporosis Foundation and others suggested that low BMI should be included in the risk assessment tools for evaluation of osteoporosis and osteoporotic fracture risk [29–31]. We found that men with BMI < 25 had 4.4 (95% CI 1.5, 12.8) times higher age-adjusted risk of osteoporosis than men with BMI ? 25. In contrast, Steinschneider et al. in a cross-sectional study reported that the correlation between BMD at the femoral neck and BMI was highly positive among postmenopausal women. A hospital-based study conducted in elderly men reported that overweight and obese men were more likely to have osteoporosis and osteopenia . The possible explanation for the discrepancies between these results might be related to populations, research designs, sampling methods, and methodological differences.
The new components which adipose tissue exerts positive effects towards BMD updates are not entirely obvious. The new putative device value from fat getting skeletal integrity probably stays in the newest part of numerous adipokines inside bone building work as a result of impact on one another creation and you may resorption. Has just, bone has been considered an enthusiastic hormonal body organ impacting weight manage and glucose homoeostasis from the measures regarding bone-derived situations such osteocalcin and you will osteopontin [23, 34–36]. The putative crosstalk anywhere between pounds in addition to bones constitutes an effective homoeostatic views system in which adipokines and molecules secreted from the osteoblasts and you will osteoclasts depict the web link from an energetic limbs-adipose axis [34–36]. Being obese is even of this BMD by the conversion process away from androgen so you’re able to the hormone estrogen , which advances bones bulk in both group [38, 39] and keeps suit plasma degrees of insulin and you will managing products along with insulin-like progress basis-1, leptin, and you may adiponectin . While doing so, carrying excess fat will bring padding to your stylish in the event of a great fall . not, this new systems where most of these events exists will still be unsure.